RES-CG and RES-Sonics: Fully Automated Sample Preparation instrument for rapid extraction of solid dose forms, gels, and liquids.
Proprietary Technology designed to enhance tortuous and turbulent flow for rapid extraction of dosage forms.
The fully automated approach to solid, semi-solid, and liquid dosage form sample preparation.
1 Health & Safety – Automated sample preparation and enclosed system reduces user exposure to harmful substances
2 Easy-load System – Minimal setup and instrument touch-time maximizes productivity
3 Barcode Workflow – Reduces errors, simplifies operation, and facilitates sample custody tracking
4 Patented Turbulent Flow Extraction – Accelerates extraction and delivers highly homogenous samples
5 Patented Crush and Grind or Sonication Technology – Provides a wide range of method flexibility for all sample types
6 Large Volume Range – Wide range of extraction volume maximises method flexibility
7 Accurate Dispensing – Gravimetric confirmation of dispensed solvent volumes ensures accuracy, provides in-process data, and comprehensive reporting
The RES uses patented turbulent flow technology, with optional ultasonication or crush and grind mechanical force to accelerate sample preparation extractions. Samples are quickly extracted, filtered, and diluted, ahead of analysis.
The RES is suitable for testing content uniformity (CU), impurity (imps), composite and bulk assay, ICH stability assay, blend and granulation uniformity, and other applications requiring a liquid extracted sample preparation.
From analytical R&D through to QA/QC laboratories, the RES improves quality of data, productivity, compliance, process standardization, and simplicity, whilst also delivering health & safety, environmental, and economic benefits.
Load the sample into the FlowCell
Load the FlowCell into the Puck
Scan the barcode and input the data
Load the puck onto the Carousel
Process the sample
The selected extraction eluent is dispensed to ASTM Class A dispensing accuracy, with gravimetric verification of solvent arrival. The extraction eluent is then circulated around the closed loop system, the turbulent flow quickly extracting the sample contained within the FlowCell.
An aliquot of solute is filtered and dispensed into a septa-sealed 22 mL primary vial. If required, the filtrate is then automatically diluted to ASTM Class A dispensing accuracy, to achieve the required concentration from 1:1 to 1:100000 dilution range.
After mixing to achieve homogeneity, a volume can be automatically dispensed into a septa-sealed 2 mL HPLC vial, or directly injected into your analyser.
Designed to highest standards to ensure regulatory and quality compliance of data integrity, validity, and repeatability.
CambTEK has worked with analytical chemists from leading Pharmaceutical Companies in the design and testing of the RES, to ensure the common concerns within the industry were addressed.
* Optional Features / Additional Cost Features
Requires low user touch-time, and 24/7 workflow increases laboratory productivity.
Support and improve your lean sigma initiatives and gain productivity.
Full in-process data, not just end-point analytical data.
Fully automated sample-in to prepared sample-out workflow, passes highly consistent results to any downstream analytical instrument.
Automated sample preparation and enclosed system reduces user exposure to harmful substances.
Automated closed system reduces analyst exposure to solvents, excipients and active pharmaceutical ingredients.
Platform technology aids compliance and consistent results, independent of user proficiency or laboratory location.
Platform technology for site and user independent standardization of results, from R&D through to manufacturing.
Processes a wide range of sample types in both single sample and bulk assay, including more challenging formulations such HPMC, PEG, PEO and laser-drilled.
Provides sample preparation front-end to any dosage form analytical workflow.
The CambTEK RES is at the cutting edge of fully automated sample preparation of dosage forms, in development and quality assurance laboratories, and manufacturing environments. From Phase 1 Development through to Manufacturing Quality Assurance, the RES will improve quality of data, and increase productivity.
The RES has been designed to prepare a vast range of dosage forms, including:
The RES uses turbulent fluidic flow with solvent quantities from 50 mL-500 mL with optional ultrasonic energy to extract samples. Pump speed is adjustable from 70 mL/min to 1 L/min approximately, giving full control of the extraction process, allowing the RES to perform a wide range of functions, including:
After extraction, the solution is filtered and the filtrate delivered to a primary 20 mL vial ready for dilution or directly to an HPLC vial for analysis. All dilution and dispensing steps are performed with gravimetric feedback, delivering high repeatability and ASTM Class A dispensing accuracy. The RES then automatically performs a cleaning and drying cycle, ready to process the next sample.
Highly repeatable liquid delivery process conforms to ASTM Class A dispensing accuracy.
Fluidics and sonication provide good equivalency to manual methods, minimizing validation requirements when transferring from manual processes to RES automation.
Automated sample preparation increases laboratory productivity, leading to greater efficiency and economic benefits.
RES delivers economic benefits by reducing manual sample preparation tasks, standardizing processes, reducing errors, and increasing laboratory productivity.
Intuitive instrument & software, with barcode-driven workflows, simplifies operation for all types of users.
All aspects of the instrument are easily configured using the intuitive Graphical User Interface (GUI), from setup to method development to operation.
Unique sample record stored in encrypted database, for integrity and protection of raw data.
21 CFR Part 11 compliant, with full user and instrument operations log. Login rights assigned depending on required permissions: Standard User, Method Developer, and Administrator.
Robust design and high component specification delivers minimal downtime and maximum reliability.
Book a presentation for a more in-depth look at the technology and application areas, and an opportunity to ask any questions you have about the system.Book a presentation
Download the full RES brochure for a full overview of the advantages offered by the RES (PDF download).Get the brochure
Advancements in Sample Preparation Techniques for Oral Dosage Forms.
Focus on innovative solutions for content uniformity and assay, semi and fully automated sample preparation.
CambTEK to launch ‘The Future of Sample Preparation’