Rapid Extraction System
The automated approach to solid, semi-solid, and liquid dosage form sample preparation.
The RES uses patented turbulent flow technology, with optional ultasonication to accelerate sample preparation extractions. Samples are quickly extracted, filtered, and diluted, ahead of analysis.
The RES is suitable for testing content uniformity (CU), impurity (imps), composite and bulk assay, ICH stability assay, blend and granulation uniformity, and other applications requiring a liquid extracted sample preparation.
From analytical R&D through to QA/QC laboratories, the RES improves quality of data, productivity, compliance, process standardization, and simplicity, whilst also delivering health & safety, environmental, and economic benefits.
- Improved quality control
- Increased productivity
- Process control
- Reproducible processes
- Improved health & safety
- Global process standardization
- Fully automated sample-in to extract-out
- Easy sample loading and tracking
- In-process gravimetric control
- Intuitive user software
- 21 CFR Part 11 compliant
- Comprehensive data logging & reporting
Ease of Use
The RES is very intuitive and easy to use. The minimal training requirement and low user touch-time leads to fast setup and operation, increased productivity, and reduced errors.
Load sample into FlowCell
Load FlowCell into puck
Scan barcode & input data
Load puck onto carousel
The selected extraction eluent is dispensed to ASTMS Class A dispensing accuracy, with gravimetric verification of solvent arrival. The extraction eluent is then circulated around the closed loop system, the turbulent flow quickly extracting the sample contained within the FlowCell. An aliquot of solute is filtered and dispensed into a septa-sealed 22 mL primary vial. If required, the filtrate is then automatically diluted to ASTMS Class A dispensing accuracy, to achieve the required concentration from 1:1 to 1:400 dilution range. After mixing to achieve homogeneity, a volume can be automatically dispensed into a septa-sealed 2 mL HPLC vial, or directly injected into your analyser.
Normal Release Tablet Demonstration
Prolonged Release Tablet Demonstration
Bulk Assay Extraction Demonstration
Powder Extraction Demonstration
Key Features & Benefits
RES automation provides the modern laboratory with a range of advantages:
Designed to highest standards to ensure regulatory and quality compliance of data integrity, validity, and repeatability.
Requires low user touch-time, and 24/7 workflow increases laboratory productivity.
Full in-process data, not just end-point analytical data.
Fully automated sample-in to prepared sample-out workflow, passes highly consistent results to any downstream analytical instrument.
Health & Safety
Automated sample preparation and enclosed system reduces user exposure to harmful substances.
Platform technology aids compliance and consistent results, independent of user proficiency or laboratory location.
Processes a wide range of sample types in both single sample and bulk assay, including more challenging formulations such HPMC, PEG, PEO and laser-drilled.
Provides sample preparation front-end to any dosage form analytical workflow.
Highly repeatable liquid delivery process conforms to ASTMS Class A dispensing accuracy.
Fluidics and sonication provide good equivalency to manual methods, minimizing validation requirements when transferring from manual processes to RES automation.
Automated sample preparation increases laboratory productivity, leading to greater efficiency and economic benefits.
Ease of Use
Intuitive instrument & software, with barcode-driven workflows, simplifies operation for all types of users.
Unique sample record stored in encrypted database, for integrity and protection of raw data.
21 CFR Part 11 compliant, with full user and instrument operations log. Login rights assigned depending on required permissions: Standard User, Method Developer, and Administrator.
Robust design and high component specification delivers minimal downtime and maximum reliability.